Erik S. Musiek, M.D., Ph.D.
circadian, clock genes, oxidative stress, neurodegeneration, Bmal1, Alzheimer`s Disease
Molecular mechanisms of neurodegeneration, with interest in circadian clock genes and oxidative stress
Dr. Musiek’s research interests focus on the molecular mechanisms of neurodegeneration, with special interests in circadian clock function and in oxidative stress. A major focus is the role of circadian clock genes in the regulation of brain oxidative stress, protein aggregation, bioenergetics, and neurodegeneration. The lab focuses on mouse models of Alzheimer`s Disease, examining how clock genes regulate amyloid-beta metabolism, synapse injury, and other pathologies. Mouse models of accelerate aging are also used to understand the molecular connections between aging, circadian function, oxidative stress, and neurodegeneration.
Musiek ES, Lim MM, Yang G, Bauer AQ, Qi L, Lee Y, Roh JH, Ortiz-Gonzalez X, Dearborn JT, Culver JP, Herzog ED, Hogenesch JB, Wozniak DF, Dikranian K, Giasson BI, Weaver DR, Holtzman DM, Fitzgerald GA. (2013) Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J. Clin Invest, 123:5389-400
Musiek ES and Holtzman DH (2012) Origins of Alzheimer`s disease: reconciling cerebrospinal fluid biomarker and neuropathology data regarding the temporal sequence of amyloid-beta and tau involvement. Curr Opin Neurol., 25; 715-20.
Musiek ES, Chen Y, Korczykowski M, Saboury B, Martinez PM, Reddin JS, Alavi A, Newberg AB, Julin P, Arnold SE, Detre JA (2011) Direct Comparison of FDG-PET and ASL-MRI in Alzheimer’s Disease. Alzheimers Dement, 8; 51-9.
Chen Y, Wolk DA, Reddin JS, Korczykowski M, Martinez PM,Musiek ES, Newberg AB, Julin P, Arnold SE, Greenberg JH, Detre JA (2011) Voxel level Comparison Of Arterial Spin Labeled Perfusion MRI And FDG-PET In Alzheimer’s Disease. Neurology, 77; 1977-85.
Musiek ES, Brooks JD, Joo M, Brunoldi E, Porta A, Zanoni G, Vidari G, Blackwell TS, Montine TJ, Milne GL, McLaughlin B, Morrow JD (2008) Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the omega-3 polyunsaturated fatty acid docosahexaenoic acid. J. Biol. Chem., 283: 19927-35.
Last Updated: 9/11/2015 9:37:06 AM