Adetunji T. Toriola, M.D., Ph.D.

Assistant Professor
Surgery
Public Health Sciences

Human and Statistical Genetics Program
Immunology Program
Molecular Genetics and Genomics Program

  • 314-286-2668

  • 8100

  • a.toriola@wustl.edu

  • https://surgery.wustl.edu/people/adetunji-toriola/

  • Biomarkers, inflammation, metabolic imbalance, mammographic density, breast cancer, colorectal cancer, prevention,

  • Associations of metabolic imbalance, inflamation with cancer etiology and survival

Research Abstract:

As a molecular cancer epidemiologist, Dr. Toriola addresses methods for use of biomarkers of energetics, metabolic imbalance, and inflammation, as well as their application in cancer etiologic and prognosis. His current research also focuses on investigating the determinants of mammographic density and breast cancer that can be targeted, with the goal of devising new breast cancer prevention strategies in premenopausal women. He has taken leading roles in studies conducted within large cohorts such as the Women’s’ Health Initiative Observational Study, Finnish Maternity Cohort, Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial and Kuopio Ischemic Heart Disease Risk Factor Study.

Selected Publications:

Alimujiang A, Imm KR, Appleton CM, Colditz GA, Berkey CS, Toriola AT. Adiposity at Age 10 and Mammographic Density among Premenopausal Women. Cancer Prev Res (Phila). 2018 May;11(5):287-294. doi: 10.1158/1940-6207.CAPR-17-0309. Epub 2018 Mar 2. PMID: 29500187.

Yang L, Toriola AT. Inflammation Modifies the Association of Obesity with Circulating 25-Hydroxyvitamin D Levels in Cancer Survivors. Obesity (Silver Spring). 2017 Nov;25 Suppl 2:S58-S65. doi: 10.1002/oby.22011. PMID: 29086515. PMCID: PMC5679285.

Toriola AT, Ziegler M, Li Y, Pollak M, Stolzenberg-Solomon R. Prediagnosis Circulating Insulin-Like Growth Factors and Pancreatic Cancer Survival. Ann Surg Oncol. 2017 Oct;24(11):3212-3219. doi: 10.1245/s10434-017-5988-y. PMID: 28681154.

Toriola AT, Dang HA, Hagermann IS, Appleton CM, Colditz GA, Luo J, Maher CA. Increased breast tissue receptor activator of nuclear factor- kB ligand (RANKL) gene expression is associated with higher mammographic density in premenopausal women. Oncotarget. 2017 May 17;8(43):73787-73792. doi: 10.18632/oncotarget.17909. eCollection 2017 Sep 26. PMID: 29088745. PMCID: PMC5650300.

Rosner B, Eliassen HA, Toriola AT, Chen WY, Hankinson SE, Willet WC, Berkey CS, Colditz GA. Weight and weight changes in early adulthood and later breast cancer risk. Int. J Cancer. 2017 140(9):2003-2014. PMID: 28133728. PMCID: PMC5798241.

Fortner RT, Schock H, Kaaks R, Lehtinen M, Pukkala E, Lakso HÅ, Tanner M, Kallio R, Joensuu H, Korpela J, Toriola AT, Hallmans G, Grankvist K, Zeleniuch-Jacquotte A, Toniolo P, Lundin E, Surcel HM. Human chorionic gonadotropin does not correlate with risk for maternal breast cancer: results from the Finnish maternity cohort. Cancer Res. 2017;77(1):134-141. PMID: 27784743PMCID: PMC5270509.

Nywening TM, Wang-Gillam A, Sanford DE, Belt BA, Panni RZ, Cusworth BM, Toriola AT, Nieman RK, Worley LA, Yano M, Fowler KJ, Lockhart AC, Suresh R, Tan BR, Lim KH, Fields RC, Strasberg SM, Hawkins WG, DeNardo DG, Goedegebuure SP, Linehan D. Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial. Lancet Oncol. 2016;17(5):651-62. doi: 10.1016/S1470-2045(16)00078-4. PMID: 27055731. PMCID: PMC5407285.

Ulrich CM, *Rankin C, *Toriola AT, Makar KW, Altug-Teber Ö, Benedetti JK, Holmes RS, Smalley SR, Blanke DS, Lenz H-J. Polymorphisms in folate-metabolizing enzymes and response to 5-fluorouracil among stage II or III rectal cancer patients (INT-0144; SWOG 9304). Cancer 2014: 1;120(21):3329-37. PMID: 25041994 *Equal contribution. PMID: 25041994. PMCID: PMC4259283.

Toriola AT, Stolzenberg-Solomon R, Dalidowitz L, Linehan D, Colditz G. Diabetes and pancreatic cancer survival: a prospective cohort-based study. Br J Cancer 2014:111(1): 181-5. PMID: 24786605 PMCID: PMC4090724.

21. Toriola AT, Cheng T-YD, Neuhouser ML, Wener MH, Zheng Y, Brown E, Miller JW, Song X, Beresford SAA, Gunter MJ, Caudill MA, Ulrich CM. Biomarkers of inflammation are associated with colorectal cancer risk in women but are not suitable as early detection markers. Int J Cancer 2013:132(11):2648-59. PMID: 23161620. PMCID: PMC3609926.

Last Updated: 9/11/2018 10:29:41 AM

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