Jeffrey Haspel, M.D., Ph.D.

Assistant Professor
Internal Medicine
Pulmonary & Critical Care

Molecular Cell Biology Program
Molecular Microbiology and Microbial Pathogenesis Program
Biochemistry, Biophysics, and Structural Biology Program

  • 8052


  • Understand the impact of time as a biological variable in the development of critical illness such as sepsis, respiratory failure and chronic inflammatory lung disease

Research Abstract:

The overall mission of our lab is to understand the impact of time as a biological variable in the development of critical illness such as sepsis, respiratory failure and chronic inflammatory lung disease. In particular, we are interested in the impact of two distinct but interrelated temporal influences: circadian rhythms and aging. Circadian rhythms are cyclic daily variations in biological function that are pervasive at all levels of biology, from behavior to gene expression. In the current ICU environment we pay little attention to circadian rhythms on the assumption that they are relevant only to healthy individuals, and similarly the chronological age of patients is not considered when designing therapies. In reality we have little information about the extent to which circadian rhythms or other temporal influences persist in ICU patients at the level of basic cellular physiology, nor do we understand the consequences of disrupting these rhythms on eventual recovery.

To fill this knowledge gap our group uses mouse models of respiratory viral infection, polymicrobial sepsis and systemic inflammation to profile circadian rhythms in gene expression and metabolism during acute illness, and to ask what happens during illness when such biological rhythms are disrupted. We also utilize mice at varying ages to define the impact of chronological age on the organism’s response to sepsis and inflammation.

Selected Publications:

Haspel JA, Chettimada S, Shaik RS, Chu JH, Raby BA, Cernadas M, Carey V, Process V, Hunninghake GM,
Ifedigbo E, Lederer JA, Englert J, Pelton A, Coronata A, Fredenburgh LE, Choi AM. Circadian rhythm
reprogramming during lung inflammation. Nat Commun. 2014 Sep 11;5:4753. PubMed PMID: 25208554;
PubMed Central PMCID: PMC4162491

Lam HC, Cloonan SM, Bhashyam AR, Haspel JA, Singh A, et al. Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. J Clin Invest. 2013 Dec;123(12):5212-30. PubMed PMID: 24200693; PubMed Central PMCID: PMC3859407.

Mofarrahi M, Guo Y, Haspel JA, Choi AM, Davis EC, et al. Autophagic flux and oxidative capacity of skeletal muscles during acute starvation. Autophagy. 2013 Oct;9(10):1604-20. PubMed PMID: 23955121.

Patel AS, Lin L, Geyer A, Haspel JA, An CH, et al. Autophagy in idiopathic pulmonary fibrosis. PLoS One. 2012;7(7):e41394. PubMed PMID: 22815997; PubMed Central PMCID: PMC3399849.

Haspel J, Shaik RS, Ifedigbo E, Nakahira K, Dolinay T, et al. Characterization of macroautophagic flux in vivo using a leupeptin-based assay. Autophagy. 2011 Jun;7(6):629-42. PubMed PMID: 21460622; PubMed Central PMCID: PMC3127049

Last Updated: 7/22/2015 2:55:27 PM

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