George B. Kyei, MB, ChB, PhD

Assistant Professor
Internal Medicine
Infectious Diseases

Molecular Microbiology and Microbial Pathogenesis Program

  • (314)-747-9867

  • (314)-747-2773

  • 8051

  • 554 McDonnell Sciences Building

  • gkyei@dom.wustl.edu

  • HIV latency and reservoir maintenance

Research Abstract:

My research interests are in HIV latency and reservoir maintenance. An important obstacle to the cure of HIV is viral
replication in long lived, quiescent immune cells such as macrophages, dendritic cells and resting T cells. These cells serve as sources of viral production once medications are discontinued, making life-long therapy a necessity. In addition, slow or inefficient replication makes the virus less susceptible to current antiretrovirals in these cell types. My research efforts are focused on (i) characterization of factors that control HIV replication in macrophages, dendritic and resting T cells and (ii) identification of cellular factors and small molecules required for HIV reactivation in latently infected cells. (iii) Characterization of the HIV reservoir.

Selected Publications:

1. George B Kyei, Xiaogang Cheng, Rashmi Ramani, Lee Ratner. Cyclin L2 is a critical HIV dependency factor in macrophages that controls SAMHD1 abundance. Cell Host Microbe. 2014. Dec 17. [Epub ahead of print]. PMID: 25532805

2. Ponpuak M, Davis AS, Roberts EA, Delgado MA, Dinkins C, Zhao Z, Virgin HW 4th, Kyei GB, Johansen T, Vergne I, Deretic V. Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties. Immunity. 2010 Mar 26;32(3):329-41.
PMID: 20206555

3. George B. Kyei, Christina Dinkins, Alexander S. Davis, Esteban Roberts, Sudha B. Singh, Chunsheng Dong, Li Wu, Eiki Kominami, Takashi Ueno, Akitsugu Yamamoto, Maurizio Federico, Antonito Panganiban, Isabelle Vergne, and Vojo Deretic. Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J. Cell Biol. 2009, Jul 186 (2) 255–268. PMID: 19635843

4. Monica A Delgado, Rasha A Elmaoued, Alexander S. Davis, George Kyei and Vojo Deretic. Toll-like receptors control autophagy. EMBO J. 2008 27(7):1110-21. PMID: 18337753

5. Alexander S. Davis, Isabelle Vergne, Sharon Master, George B Kyei, Jennifer Chua and Vojo Deretic. Mechanism of Inducible Nitric Oxide Synthase Exclusion from Mycobacterial Phagosomes. Plos Pathogens, 2007, 3(12): e186. doi:10.1371. PMID: 18069890

6. Deretic V, Singh S, Master S, Kyei G, Davis A, Naylor J, de Haro S, Harris J, Delgado M, Roberts E, Vergne I. Phosphoinositides in phagolysosome and autophagosome biogenesis. Biochem Soc Symp. 2007;(74):141-8. PMID: 17233587

7. Kyei GB, Vergne I, Chua J, Roberts E, Harris J, Junutula JR, Deretic V. Rab14 is critical for maintenance of Mycobacterium tuberculosis phagosome maturation arrest. EMBO J. 2006 Nov 15;25(22):5250-9.
PMID: 17082769

8. Roberts EA, Chua J, Kyei GB, Deretic V. Higher order Rab programming in phagolysosome biogenesis. J Cell Biol. 2006 Sep 25;174(7):923-9. PMID: 16982798

9. Vergne I, Singh S, Roberts E, Kyei G, Master S, Harris J, de Haro S, Naylor J, Davis A, Delgado M, Deretic V. Autophagy in immune defense against Mycobacterium tuberculosis. Autophagy. 2006 Jul-Sep;2(3):175-8.
PMID: 16874111

10. Deretic V, Singh S, Master S, Harris J, Roberts E, Kyei G, Davis A, de Haro S, Naylor J, Lee HH, Vergne I. Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defense mechanism. Cell Microbiol. 2006 May;8(5):719-27. PMID: 16611222

11. Deretic V, Vergne I, Chua J, Master S, Singh SB, Fazio JA, Kyei G. Endosomal membrane traffic: convergence point targeted by Mycobacterium tuberculosis and HIV. Cell Microbiol. 2004 Nov;6(11):999-1009. PMID: 15469429

Last Updated: 8/13/2015 11:42:03 AM

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