Richard D. Vierstra, Ph.D.

George and Charmaine Mallinckrodt Professor
Biology
Biochemistry and Molecular Biophysics

Plant and Microbial Biosciences Program
Biochemistry, Biophysics, and Structural Biology Program
Molecular Cell Biology Program

  • 314 935-5058

  • 1137

  • rdvierstra@wustl.edu

  • Defining how ubiquitin and other post-translational modifiers contribute to cellular regulation and turnover and how the phytochrome photoreceptor system controls plant and microbial development.

Research Abstract:

Our laboratory attempts to define how ubiquitin and other post-translational modifiers such as SUMO and the ATG8/12 autophagic components contribute to cellular regulation and turnover and how the phytochrome photoreceptor system controls plant and microbial development. We primarily use Arabidopsis thaliana and maize (Zea mays) as the model in combination with a wide range of experimental approaches, including genetics,
genomics, transcriptomics, biochemistry, cell biology and bioinformatics together with in-depth proteomic and structure-based methods such mass spectrometry, x-ray crystallography and NMR spectroscopy.

Selected Publications:

Eat or be eaten: The autophagic plight of inactive 26S proteasomes. Marshall RS, Vierstra RD. Autophagy. 2015 Oct 3;11(10):1927-8. doi: 10.1080/15548627.2015.1078961. PMID: 26291247

Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis. Marshall RS, Li F, Gemperline DC, Book AJ, Vierstra RD. Mol Cell. 2015 Jun 18;58(6):1053-66. doi: 10.1016/j.molcel.2015.04.023. Epub 2015 May 21. PMID: 26004230

Autophagic recycling plays a central role in maize nitrogen remobilization. Li F, Chung T, Pennington JG, Federico ML, Kaeppler HF, Kaeppler SM, Otegui MS, Vierstra RD. Plant Cell. 2015 May;27(5):1389-408. doi: 10.1105/tpc.15.00158. Epub 2015 May 5. PMID: 25944100

X-ray radiation induces deprotonation of the bilin chromophore in crystalline D. radiodurans phytochrome. Li F, Burgie ES, Yu T, Héroux A, Schatz GC, Vierstra RD, Orville AM. J Am Chem Soc. 2015 Mar 4;137(8):2792-5. doi: 10.1021/ja510923m. Epub 2015 Feb 18. PMID: 25650486

The endosomal protein CHARGED MULTIVESICULAR BODY PROTEIN1 regulates the autophagic turnover of plastids in Arabidopsis. Spitzer C, Li F, Buono R, Roschzttardtz H, Chung T, Zhang M, Osteryoung KW, Vierstra RD, Otegui MS. Plant Cell. 2015 Feb;27(2):391-402. doi: 10.1105/tpc.114.135939. Epub 2015 Feb 3. PMID: 256494

Last Updated: 12/7/2015 10:29:04 AM

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