Tim R Peterson, Ph.D.
Bone & Mineral Diseases
Molecular Genetics and Genomics Program
Computational and Systems Biology Program
Molecular Cell Biology Program
Genomics,Metabolomics,Aging,Mental Health,CRISPR,Quantified Self,Programming,Systems Biology,Computational Biology,High-Throughput Sequencing
genomics, metabolomics, and the quantified self in aging and mental health
Our group focuses on aging and mental health, two increasingly pressing quality of life issues. Core competencies: molecular biology and programming.
1. 10X Lifespan: Manipulating the leading aging pathway, insulin/mTOR, causes a 0.1X lifespan extension. It is unclear whether this extension adds to quality years. We aim for a 10X extension of healthy living. This project is discipline agnostic, meaning we are considering theoretical, organismal, societal, and environmental approach.
2. A Molecular Diagnostic for Mood: Mental health professionals lack a rigorous diagnostic tool like physicians have with glucose, cholesterol, and cell number measurements for Diabetes, Cardiovascular disease, and Cancer, respectively. We aim to change that.
3. Disruptive Innovation of Blockbuster Drugs: Blockbuster drugs like the SSRIs/Lithium (Depression/Bipolar Disorder), Statins (CVD), Bisphosphonates (bone-involving diseases like Osteoporosis), Biguanides (Diabetes) are incumbent medicines that often have numerous reasons not to use them: they can have considerable side effects, simply not work well, and be expensive. We employ multiple technologies: CRISPR and other genetics, metabolic, computational systems approaches to identify targets for high-impact areas such as Osteoporosis and Depression/Bipolar Disorder. We have identified new targets for the Bisphosphonates and Lithium and are elucidating their biology.
Peterson TR, Sengupta, Harris TE, Carmack AE, Kang SA, Madden KL, Carpenter AE, Guertin DA, Finck BN, Sabatini DM. mTORC1 regulates lipin 1 localization to control the SREBP pathway. Cell. 2011 Aug 5;146(3):408-20. PMID: 21816276.
Sengupta S, Peterson TR, Laplante M, Oh S, Sabatini DM. mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature. 2010 Dec 23;468(7327):1100-4. PMID: 21179166.
Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS, Sabatini DM. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell. 2009 May 29;137(5):873-86. PMID: 19446321.
Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008 Jun 13;320(5882):1496-501. PMID: 18497260.
Last Updated: 10/24/2016 9:47:38 AM