Aadel A. Chaudhuri, M.D., Ph.D.

Assistant Professor
Radiation Oncology

Computational and Systems Biology Program
Molecular Genetics and Genomics Program
Cancer Biology Program
Human and Statistical Genetics Program

Research Abstract:

Our group focuses on translational cancer genomics. Specifically we are interested in analyzing and tracking cell-free circulating tumor DNA (ctDNA) as a method for detecting cancer relapse early, and identifying responses to cancer treatment sensitively. Members of my group focus on applying the Cancer Personalized Profiling by deep Sequencing (CAPP-Seq) method to detect molecular residual disease (MRD), and in methodological advances to apply ctDNA technology to more diverse clinical scenarios including early cancer detection. We are also interested in applying digital cytometric methods, including CIBERSORTx, to query composition of the tumor microenvironment from bulk RNA sequencing data. All of our research involves analysis of human clinical samples/data and clinical correlation with the goal of improving cancer patient outcomes. For more information, visit our website: https://chaudhurilab.wustl.edu.

Selected Publications:

Chaudhuri AA, Chabon JJ, Lovejoy AF, Newman AM, Stehr H, Azad TD, Khodadoust MS, Esfahani MS, Liu CL, Zhou L, Scherer F, Kurtz DM, Say C, Carter JN, Merriott DJ, Dudley JC, Binkley MS, Modlin L, Padda SK, Gensheimer MF, West RB, Shrager JB, Neal JW, Wakelee HA, Loo BW Jr, Alizadeh AA, Diehn M. Early Detection of Molecular Residual Disease in Localized Lung Cancer by Circulating Tumor DNA Profiling. Cancer Discovery. 2017; 7(12):1394-1403. PMCID: PMC5895851

Chin R, Chen K, Usmani A, Chua C, Harris PK, Binkley MS, Azad TD, Dudley JC, Chaudhuri AA. Detection of Solid Tumor Molecular Residual Disease using ctDNA. Molecular Diagnosis & Therapy. 2019: 23(3):311-331. PMCID: PMC6561896

Azad TD, Chaudhuri AA, Fang P, Qiao Y, Esfahani MS, Chabon JJ, Hamilton EG, Yang YD, Lovejoy A, Newman AM, Kurtz DM, Jin M, Schroers-Martin J, Stehr H, Liu CL, Bik-Yu Hui A, Patel V, Maru D, Lin SH, Alizadeh AA, Diehn M. Circulating tumor DNA analysis for detection of minimal residual disease after chemoradiotherapy for localized esophageal cancer. Gastroenterology. 2019 Nov 8. PMID: 31711920

Last Updated: 12/19/2019 1:28:34 PM

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