Yin Cao, ScD, MPH

Associate Professor
Public Health Sciences
Internal Medicine

Biomedical Informatics and Data Science Program
Computational and Systems Biology Program
Molecular Microbiology and Microbial Pathogenesis Program
Cancer Biology Program

  • 314-747-3925

  • Taylor Avenue Building, 2315W

  • yin.cao@wustl.edu

  • https://caolab.wustl.edu/

  • https://twitter.com/yincaoscd

  • Systems and translational cancer epidemiology, microbiome, inflammation and immune-metabolic networks

  • Novel genetic, microbial, and lifestyle risk factors for lung and gastrointestinal cancers leveraging large-scale clinical and population-based cohorts with deep genomic and phenotypic data

Research Abstract:

Our research group specializes in systems and translational cancer epidemiology with an overarching goal to develop precision-based cancer prevention/control strategies. Our current projects incorporate novel high-throughput technologies (genomics, microbiome, proteomics, accelerometers) into large-scale collaborative population-based/clinical studies to address provocative questions in cancer prevention, including but not limited to the risk factors, preventive agents, and biomarkers for sporadic cancers among younger adults, the biological basis for cancer disparity, and the role of host-microbial interactions in carcinogenesis.

Selected Publications:

Tian R, Wiley B, Liu J, Zong X, Truong B, Zhao S, Uddin MM, Niroula A, Miller CA, Mukherjee S, Heiden BT, Luo JR, Puri V, Kozower BD, Walter MJ, Ding L, Link DC, Amos CI, Ebert BL, Govindan R, Natarajan P, Bolton KL, Cao Y. Clonal hematopoiesis and risk of incident lung cancer. Journal of Clinical Oncology. 2022 Dec 8. PMID: 36480766

Hur J, Otegbeye E, Joh HK, Nimptsch K, Ng K, Ogino S, Meyerhardt JA, Chan AT, Willett WC, Wu K, Giovannucci E, Cao Y. Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women. Gut. 2021 May 6;gutjnl-2020-323450. PMID: 33958435

Akimoto N, Ugai T, Zhong R, Hamada T, Fujiyoshi K, Giannakis M, Wu K, Cao Y*, Ng K*, and Ogino S* (co-senior author). Rising incidence of early-onset colorectal cancer -- a call to action. Nature Reviews Clinical Oncology. 2020 Nov 20. PubMed PMID: 33219329

Zheng X, Hur J, Nguyen LH, Liu J, Song M, Wu K, Smith-Warner SA, Ogino S, Willett W, Chan AT, Giovannucci E, Cao Y. Comprehensive assessment of diet quality and risk of precursors of early-onset colorectal cancer. Journal of National Cancer Institute. 2020 Nov 2. PubMed PMID: 33136160

Chen H, Zheng X, Zong X, Li Z, Li N, Hur J, Fritz C, Chapman W, Nickel KB, Tipping A, Colditz GA, Giovannucci EL, Olsen MA, Fields RC, Cao Y. Metabolic syndrome, metabolic comorbid conditions, and risk of early-onset colorectal cancer. Gut. 2020 Oct 9. PubMed PMID: 33037055

Yang L, Cao C, Kantor ED, Nguyen LH, Zheng X, Park Y, Giovannucci EL, Matthews CE, Colditz GA, Cao Y. Trends in sedentary behavior among the US population, 2001-2016. JAMA. 2019 Apr 23;321(16):1587-1597. PubMed PMCID: PMC6487546

Liu PH, Wu K, Ng K, Zauber AG, Nguyen LH, Song M, He X, Fuchs CS, Ogino S, Willett WC, Chan AT, Giovannucci EL, Cao Y. Association of obesity with risk of early-onset colorectal cancer among women. JAMA Oncology. 2019 Jan 1;5(1):37-44. PubMed PMCID: PMC6382547

Hidaka A, Harrison TA, Cao Y, Sakoda LC, Barfield R, ..., Sun W, Hsu L, Buchanan DD, Campbell PT, Peters U. Intake of dietary fruit, vegetables, and fiber and risk of colorectal cancer according to molecular subtypes: a pooled analysis of 9 studies. Cancer Res. 2020. Cancer Res. 2020 Oct 15;80(20). PubMed PMID: 32816852

Zaidi SH, Harrison TA, Phipps AI, Steinfelder R, Trinh QM,... Cao Y, ..., Campbell PT, Thibodeau SN, Sun W, Hudson TJ, Peters U. Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival. Nature Communications. 2020 Jul 20;11(1):3644. PubMed PMCID: PMC7371703

Cao Y, Wu K, Mehta R, Drew DA, Song M, Lochhead P, Nguyen LH, Izard J, Fuchs CS, Ogino S, Garrett WS, Huttenhower C, Ogino S, Giovannucci EL, Chan AT. Long-term use of antibiotics and risk of colorectal adenoma. Gut. 2018 Apr;67(4):672-678. PubMed PMCID: PMC5628103

Hamada T*, Cao Y*, Qian ZR*, Masugi Y* (co-first authors), Nowak JA, ...Wang M, Chan AT, Fuchs CS, Nishihara R, Ogino S. Aspirin use and colorectal cancer survival according to tumor CD274 (PD-L1) expression status. Journal of Clinical Oncology. 2017 Jun 1;35(16):1836-1844. PubMed PMCID: PMC5455595

Mima K*, Nishihara R*, Qian ZR*, Cao Y* (co-first authors), Sukawa Y, ...,Meyerson M, Meyerhardt JA, Chan AT, Fuchs CS, Ogino S. Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis. Gut. 2016 Dec;65(12):1973-1980. PubMed PMCID: PMC4769120

Cao Y, Nishihara R, Qian ZR, Song M, Mima K, Inamura K, Nowak JA, Drew DA, Lochhead P, Nosho K, Morikawa T, Zhang X, Wu K, Wang M, Garrett WS, Giovannucci EL, Fuchs CS, Chan AT, Ogino S. Regular aspirin use associates with lower risk of colorectal cancers with low numbers of tumor-infiltrating lymphocytes. Gastroenterology. 2016 Nov;151(5):879-892.e4. PubMed PMCID: PMC5159194

Cao Y, Willett WC, Rimm EB, Stampfer MJ, Giovannucci EL. Light to moderate intake of alcohol, drinking patterns, and risk of cancer: results from two prospective US cohort studies. BMJ. 2015 Aug 18;351:h4238. PubMed PMCID: PMC4540790

Last Updated: 12/12/2022 5:15:54 PM

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