Jessica M. Silva-Fisher, Ph.D.

Assistant Professor
Internal Medicine
Oncology

Cancer Biology Program
Molecular Genetics and Genomics Program
Molecular Cell Biology Program

  • 314-273-4216

  • Room 9940, Wohl Clinic Building

  • silvajm@wustl.edu

  • https://www.silvafisherlab.com/

  • Cancer metastasis, multiple myeloma, breast cancer, long non-coding RNAs, RNA modifications, genomics

  • Long non-coding RNAs and RNA modifications in cancer metastasis and relapse

Research Abstract:

Our Mission is to ask and answer critical questions in identifying why and how cancer metastasizes. We do this by conducting innovative and advanced research in a welcoming, inclusive, and supportive research environment.

Our Research focus is to study the basic mechanisms of RNAs including non-protein coding genes called long non-coding RNAs (lncRNAs) in multiple myeloma and late-stage relapse breast cancer to target them and use them for new cancer treatments.

We use bioinformatic and wet-lab approaches (RNA sequencing, single-cell RNA sequencing, Chromatin immunoprecipitation (ChIP) sequencing, and RNA immunoprecipitation (RIP) sequencing, m6A enhanced crosslinking immunoprecipitation sequencing(m6A eCLIP seq) etc.) to identify de-regulated RNAs and their associated protein interactions and modifications. We then conduct in vitro molecular biology assays to determine their functions and mechanisms in the cell and apply these to mouse models. This information is then used to target the RNA using novel RNA antisense oligo therapies for future use as novel therapies.

Mentorship and Commitment to Diversity Statement:
Diversity, Equity, and Inclusion are core values in the Dr. Silva-Fisher lab. Our lab understands, accepts, and values the differences between people including those of different races, ethnicities, genders, ages, religions, disabilities, and sexual orientations. Sexism, racism and hate have no place in our lab. We aim to be inclusive in the workplace as a collaborative, supportive, and respectful environment that increases the participation and contribution of all staff and trainees.


In collaboration with the Department of Medicine and The Office of Inclusion and Diversity we seek to promote and support these values within the lab and beyond. This is accomplished by providing resources, available courses, mentorship, and career development.

Dr. Silva-Fisher has a long history of conducting and participating in diversity and inclusion efforts. She was the Co-Chair of the Department of Medicine Trainee Inclusion and Cultural Awareness Task Force and is the Director of the Mentorship to Enhance Diversity in Academia (MEDA)Program. 

She has also been highlighted in the Molecular Cell  Journal where she gives her thoughts and experiences being an underrepresented minority in the sciences.

She also serves as a Mentor and sits on the DEI committee for the RNA Society. 

Career Development: An individual development plan will be created for trainees (staff are welcomed to participate as well) in the laboratory. This will be facilitated by using Science Careers myIDP. Dr. Silva-Fisher will have yearly meetings with trainees to about career development progress.

Selected Publications:

Selected Scientific Publications
Eteleeb A, Tang C, Thunguntula P, Gelev K, Nielsen T, Perou C, Reis-Filho J, Ellis M, Mardis E, and Silva-Fisher J*, Maher C*, LINC00355 promotes late-stage relapse in estrogen receptor positive breast cancer patients. npj Breast Cancer, 2022 8:49. doi: 10.1038/s41523-022-00412-2

Long Non-Coding RNA RAMS11 Promotes Metastatic Colorectal Cancer Progression
Silva-Fisher JM, Dang HX, White NM, Strand MS, Krasnick BA, Rozycki EB, Jeffers GGL, Grossman JG, Highkin MK, Tang C, Cabanski CR, Eteleeb A, Mudd J, Goedegebuure SP, Luo J, Mardis ER, Wilson RK, Ley TJ, Lockhart AC, Fields RC, Maher CA
Nat Commun 2020 May 1;11(1):2156

Pan-Cancer Transcriptome Analysis Reveals Long Noncoding RNAs With Conserved Function
Cabanski CR, White NM, Dang HX, Silva-Fisher JM, Rauck CE, Cicka D, Maher CA
RNA Biol 2015;12(6):628-42

Transcriptome Sequencing Reveals Altered Long Intergenic Non-Coding RNAs in Lung Cancer
White NM, Cabanski CR, Silva-Fisher JM, Dang HX, Govindan R, Maher CA
Genome Biol 2014 Aug 13;15(8):429

LSINCT5 Is Over Expressed in Breast and Ovarian Cancer and Affects Cellular Proliferation
Silva JM, Boczek NJ, Berres MW, Ma X, Smith DI
RNA Biol 2011 May-Jun;8(3):496-505

Long non-coding RNAs and Cancer
Silva JM, Smith D
In: Kevin V. Morris (Ed), Long Non-coding RNAs: Regulation of Gene Expression and Drivers of Natural Selection, (Chapter 9), The Scripps Research Institute, La Jolla, California, Caister Academic Press, 2011

Identification of Long Stress-Induced Non-Coding Transcripts That Have Altered Expression in Cancer
Silva JM, Perez DS, Pritchett JR, Halling ML, Tang H, Smith DI
Genomics 2010 Jun;95(6):355-62

Akt-Induced Tamoxifen Resistance Is Associated With Altered FKHR Regulation
Silva J, Cavazos DA, Donzis E, Friedrichs WE, Marciniak R, deGraffenried LA
Cancer Invest 2007;25(7):569-73

Inhibition of mTOR Activity Restores Tamoxifen Response in Breast Cancer Cells With Aberrant Akt Activity
deGraffenried LA, Friedrichs WE, Russell DH, Donzis EJ, Middleton AK, Silva JM, Roth RA, Hidalgo M
Clin Cancer Res 2004 Dec 1;10(23):8059-67

NF-Kappa B Inhibition Markedly Enhances Sensitivity of Resistant Breast Cancer Tumor Cells to Tamoxifen
deGraffenried LA, Chandrasekar B, Friedrichs WE, Donzis E, Silva J, Hidalgo M, Freeman JW, Weiss GR
Ann Oncol 2004 Jun;15(6):885-90

Eicosapentaenoic Acid Restores Tamoxifen Sensitivity in Breast Cancer Cells With High Akt Activity
deGraffenried LA, Friedrichs WE, Fulcher L, Fernandes G, Silva JM, Peralba JM, Hidalgo M
Ann Oncol 2003 Jul;14(7):1051-6

Selected Editorials on Diversity
Voices on Diversity: Multiple Paths to Becoming a Scientist
Silva-Fisher J, Nervo LM, Addo T, Guerra A, Walker M, Guerrier S, McGill L, Brooks D, Joseph J, Johnson J, Ayombil F, Odinammadu K
Mol Cell 2020 Dec 3;80(5):752-757

Silva-Fisher J, Guerrier S, Nervo LM, Guerra A, McGill L, Brooks D, Joseph J, Walker M, Ayombil F, Odinammadu K. Voices on Diversity: Combating Racial Inequality to Increase Diversity. Mol Cell. 2021 Jan 7;81(1):1-5. doi: 10.1016/j.molcel.2020.12.022. PubMed PMID: 33417852.



Last Updated: 9/28/2022 9:29:19 AM

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