Timothy M. Miller, M.D., Ph.D.

Neuromuscular Disorders

Neurosciences Program
Molecular Cell Biology Program
Biochemistry, Biophysics, and Structural Biology Program

  • 314-362-8169

  • 314-362-8168

  • 314-362-3279

  • 117 Biotechnology Building

  • millert@neuro.wustl.edu

  • http://millerlab.wustl.edu/

  • ALS (amyotrophic lateral sclerosis), SOD1, TDP-43, C9ORF72, miRNA, Tau, Dementia, Neurodegeneration, Antisense oligonucleotides

  • Mechanisms of neurodegeneration and targeted therapies for neurodegenerative diseases

Research Abstract:

The Miller Laboratory is dedicated to understanding neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and dementias. We use a variety of cell biological and in vivo techniques to understand mechanisms of disease and have focused recently on miRNAs, protein kinetics, splice isoforms, and inflammation. We are interested in the translational potential of many of these studies and continue to develop RNA-targeted therapeutic strategies for neurodegenerative diseases, using antisense oligonucleotides.

Selected Publications:

Hoye ML, Regan MR, Jensen LA, Lake AM, Reddy LV, Vidensky S, Richard JP, Maragakis NJ, Rothstein JD, Dougherty JD, Miller TM.
Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis. Brain. 2018

McCampbell A, Cole T, Wegener AJ, Tomassy GS, Setnicka A, Farley BJ, Schoch KM, Hoye ML, Shabsovich M, Sun L, Luo Y, Zhang M, Thankamony S, Salzman DW, Cudkowicz M, Graham DL, Bennett CF, Kordasiewicz HB, Swayze EE, Miller TM.
Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models.
The Journal of Clinical Investigation. 2018.

DeVos SL, Miller RL, Schoch KM, Holmes BB, Kebodeaux CS, Wegener AJ, Chen G, Shen T, Kordasiewicz HB, Tran H, Nichols B, Zanardi TA, Swayze EE, Bennett CF, Diamond MI, Miller TM.
Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy.
Science Translational Medicine. 2017

Schoch K, DeVos S, Miller R, Chun S, Norrbom M, Wozniak D, Dawson H, Bennett C, Rigo F, Miller TM.
Increased 4R-tau induces pathological changes in a human-tau mouse model.
Neuron. 2016.

Crisp MJ, Mawuenyega KG, Patterson BW, Reddy NC, Chott R, Self WK, Weihl CC, Jockel-Balsarotti J, Varadhachary AS, Bucelli RC, Yarasheski KE, Bateman RJ, Miller TM.
In vivo kinetic approach reveals slow SOD1 turnover in the CNS.
The Journal of Clinical Investigation 2015.

For a full list of publications and PDFs, https://millerlab.wustl.edu/research/publications/

Last Updated: 8/31/2018 8:54:14 AM

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