Mayssa H. Mokalled, Ph.D.

Assistant Professor
Developmental Biology

Developmental, Regenerative and Stem Cell Biology Program
Neurosciences Program
Molecular Genetics and Genomics Program

  • 314-273-1835

  • 314-273-1836

  • 3601 Cancer Research Building

  • mmokalled@wustl.edu

  • https://www.mokalledlab.com/

  • Mechanisms of neural regeneration using zebrafish and mouse model systems

Research Abstract:

The Mokalled lab aims at exploring and promoting spinal cord repair after injury or disease.

Regenerative capacity is unevenly distributed across organisms. While mammals exhibit limited abilities to repair spinal cord damage, adult zebrafish are capable of remarkable cellular and functional regeneration after complete spinal cord transection.

Our current research projects are focused on:

1) Elucidating cellular and molecular mechanisms of glial bridging after spinal cord transection in zebrafish.

2) Investigating mechanisms of neurogenesis and functional repair in zebrafish.

3) Performing comparative studies to uncover the bases for differential regenerative capacity between the highly regenerative zebrafish and poorly regenerative mouse models.

The central goal of our research is to inspire and guide innovative molecular and cellular approaches for spinal cord treatment.

Selected Publications:

- Mokalled MH.*, Patra C., Dickson AL., Endo T., Stainier DY. and Poss KD. Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish. Science. 2016. 354(6312);630-4. PMID: 27811277.

* Featured by the American Association for the Advancement of Science (AAAS), the NIH Director’s Blog, The Naked Scientists, and others.

* Williams PR. and He Z.Building bridges to regenerate axons. Science. 2016. 354(6312);544-5. Perspective article.

- Mokalled MH.*, Carroll KJ.*, Cenik BK., Liu N., Olson EN.# and Bassel-Duby R.#. Myocardinrelated transcription factors are required for cardiac development and function. Dev Biol. 2015. pii: S0012-1606(15)30173-1. PMID: 26386146.

- Mokalled MH., Johnson AN., Creemers E. and Olson EN. MASTR directs MyoD-dependent satellite cell differentiation during skeletal muscle regeneration. Genes Dev. 2012. 26(2):190-202. PMID: 22279050.

- Mokalled MH., Johnson A., Kim Y., Oh J. and Olson EN. Myocardin-related transcription factors regulate the Cdk5/Pctaire-1 kinase cascade to control neurite outgrowth, neuronal migration and brain development. Development. 2010. 137(14):2365-74. PMID: 20534669.

Last Updated: 1/12/2018 12:05:33 PM

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