Silvia Jansen, Ph.D.

Assistant Professor
Cell Biology and Physiology

Molecular Cell Biology Program
Biochemistry, Biophysics, and Structural Biology Program

  • 314 273-1853

  • silvia.jansen@wustl.edu

  • https://silviajansen.wixsite.com/jansen-lab

  • actin cytoskeleton, microtubule, single molecule, live cell imaging, protein transport, Golgi, confocal microscopy

  • we study the molecular mechanisms that regulate the architecture, dimensions and dynamics of actin filament networks, and tune them to support essential cellular functions including cell migration, intracellular trafficking and cytokinesis.

Research Abstract:

The actin cytoskeleton is an intricate polymer system that can be assembled into many different structures, ranging from stable stress fibers that locally support cell adhesion, to the extensive and dynamic branched network at the leading edge that drives cell migration. However, a question that keeps intriguing the field is how this plethora of structures, each with their own particular turnover rates and physical properties, can be assembled in the same cytosol from the same basic building blocks, i.e. actin filaments. In other words, what determines the fate of an actin filament?

In the Jansen lab, we are using a combination of genetics, biomimetic systems, cell imaging, multi-color in vitro TIRF microscopy and single molecule techniques to investigate how two important, but heavily understudied families of actin-binding proteins, the Tropomyosins and the Coronins, play a role as regulatory hubs that generate different actin filament populations that are optimally suited to mediate intracellular trafficking, cell migration, cytokinesis or cell adhesion. For more information on past and current projects, go to https://silviajansen.wixsite.com/jansen-lab.

Selected Publications:

Jansen S, Collins A, Chin SM, Ydenberg CA, Gelles J, Goode BL. Single-molecule imaging of a three-component ordered actin disassembly mechanism. (2015) Nat Commun, 6: 7202.

Chin SM, Jansen S, Goode BL. TIRF microscopy analysis of human Cof1, Cof2 and ADF effects on actin filament severing and turnover. (2016) J Mol Biol, 428 (8), 1604-16.

Jansen S, Collins A, Golden L, Sokolova O, Goode BL. Structure and mechanism of mouse cyclase-associated protein (CAP1) in regulating actin dynamics. (2014) J Biol Chem, 289(44):30732-42.

Jansen S, Collins A, Yang C, Rebowski G, Svitkina T, Dominguez R. Mechanism of actin filament bundling by fascin. (2011) J Biol Chem, 26;286(34): 30087-96.

Last Updated: 5/29/2018 10:25:41 AM

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