Kristine M. Wylie, Ph.D.

Assistant Professor
Pediatrics
Infectious Diseases

Molecular Microbiology and Microbial Pathogenesis Program

  • 6110 McDonnell Pediatric Research Building

  • kwylie@wustl.edu

  • Host-microbe dynamics during pregnancy

Research Abstract:

The Wylie Lab studies the microbiome, microbial infections, and maternal host response during pregnancy. We have particular interest in the human virome, and we are interested in developing and applying innovative technologies for the study of viral communities, viral dynamics, and host response. We are carrying out in vitro studies to understand herpesvirus and papillomavirus infections during pregnancy. We use microbial genomics, in vitro cell culture, and animal models in our work.

Our recent work demonstrated associations between viral communities in the vagina with preterm birth, which we studied using the ViroCap enrichment method that we developed. We are currently pursuing studies to uncover the mechanisms underlying this association. Our goals are (a) to develop metrics for predicting women at risk for preterm birth, (b) understand the biology of virus-host interactions in pregnancy.

Selected Publications:

Wylie KM, Blankenship SA, Tuuli MG, Macones GA, Stout MJ. Evaluation of patient- versus provider-collected vaginal swabs for microbiome analysis during pregnancy. BMC Res Notes. 2018;11(1):706.

Wylie KM, Wylie TN, Cahill AG, Macones GA, Tuuli MG, Stout MJ. The vaginal eukaryotic DNA virome and preterm birth. Am J Obstet Gynecol. 2018.

Wyczalkowski MA, Wylie KM, Cao S, McLellan MD, Flynn J, Huang M, Ye K, Fan X, Chen K, Wendl MC, Ding L. BreakPoint Surveyor: A Pipeline for Structural Variant Visualization. Bioinformatics. 2017.

Stout MJ, Zhou Y, Wylie KM, Tarr PI, Macones GA, Tuuli MG. Early pregnancy vaginal microbiome trends and preterm birth. Am J Obstet Gynecol. 2017.

Cao, S, Wendl, MC, Wyczalkowski, MA, Wylie, K, Ye, K, Jayasinghe, R, Zie, M, Wu, S, Niu, B, Grubb, R 3rd, Johnson, KJ, Gay, H, Chen, K, Rader, JS, DiPersio, JF, Chen, F, Ding, L. Divergent viral presentation among human tumors and adjacent normal tissues Sci Rep. 2016;6:28294.

Last Updated: 8/14/2019 1:53:35 PM

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