Jonathan R. Brestoff, M.D., Ph.D., MPH.

Assistant Professor
Pathology and Immunology

Immunology Program
Molecular Cell Biology Program
Neurosciences Program

  • 314-273-1281

  • 3710 West Building

  • brestoff@wustl.edu

  • www.brestofflab.com

  • @BrestoffLab

  • Immunometabolism, Mitochondria, White/beige/brown adipose tissue, Innate immunity, Macrophages, Obesity

  • Understanding how immune cells and metabolic organs interact to maintain normal metabolism and to support adaptation to physiologic challenges

Research Abstract:

The immune system is able to control the function of various metabolic organs and contributes to metabolic abnormalities seen in diseases such as obesity and type 2 diabetes. The Brestoff Lab’s research focuses on understanding how immune cells and metabolic organs interact to maintain normal metabolism and to support adaptation to physiologic challenges such as high-fat diet feeding, changes in environmental temperature, and fasting. We employ cutting-edge techniques in immunology, metabolism, and mitochondria biology to study the immunometabolic pathways that are required for metabolic health and that contribute to disease pathogenesis. Ultimately, our goal is to discover novel biological pathways that can be targeted therapeutically or that can be leveraged to develop new diagnostic tests.

Selected Publications:

Li Y, ZoLi Y, Zou W, Brestoff JR, Rohatgi N, Wu X, Atkinson JP, Harris CA, Teitelbaum SL Fat-produced adipsin regulates inflammatory arthritis. Cell Rep. 2019; 27(10): 2809-2816.

Wilen CB, Lee S, Hsieh LY, Orchard RC, Desai C, Hykes BL Jr, McAllaster MR, Balce DR, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC, Zhang X, Wang YT, MacDuff DA, Kreamalmayer D, Howitt MR, Cadwell K, Allen PM, Handley SA, Campagne MvL, Baldridge MT, Virgin HW. Tropism for tuft cells determines immune promotion of norovirus pathogenesis. Science. 2018; 360(6385): 204-208.

Moriyama S, Brestoff JR, Flamar AL, Moeller JB, Klose CSN, Rankin LC, Yudanin NA, Monticelli LA, Putzel GG, Rodewald HR, Artis D. 2-adrenergic receptor-mediated negative regulation of group 2 innate lymphoid cell responses. Science. 2018; 359(6379): 1056-1061.

Brestoff JR#, Tesfazghi M, Zaydman MA, Jackups Jr R, Kim BS, Scott MG, Gronowski AM, Grossman BJ. The B antigen protects against the development of red meat allergy. J Allergy Clin Immunol Pract. 2018; 6(5): 1790-1791.e3. #Corresponding author.

Oetjen LK, Mack MR, Whelan TM, Wang PL, Niu H, Feng J, Xu AZ, Tripathi SV, Guo CJ, Luo J, Brestoff JR, Schaffer A, Hsieh C, Gereau RW, Miller MJ, Hu H, Davidson S, Liu Q and Kim BS. Neuronal IL-4Rα and JAK1 signaling mediate chronic itch. Cell. 2017; 171(1): 217-228.

Williams J*, Elvington AF*, Ivanov S*, Kessler S, Luehmann H, Baba O, Saunders BT, Kim K, Johnson MW, Craft CS, Choi J, Sorci-Thomas MG, Zinselmeyer BH, Brestoff JR, Liu Yongjian, Randolph GJ. Thermoneutrality but not UCP1 deficiency suppresses monocyte mobilization into blood. Circ Res. 2017; 121(6): 662-676. *Equal contributions

Brestoff JR#, Zaydman MA, Scott MG and Gronowski AM. Diagnosis of red meat allergy with antigen-specific IgE tests in serum. J Allergy Clin Immunol. 2017; 140(2): 608-609. #Corresponding author.

Last Updated: 1/14/2020 2:38:16 PM

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